This requires spending Ability Points and Greater Mutagens based on the type of Mutation you wish to research. Complete the quest to acquire the Mutation tree in your Character menu.Įach Mutation must be researched before it can be equipped. After reading the letter, the aforementioned quest will become available. After playing through a portion of the Blood and Wine main story, a messenger will deliver a letter to Geralt. In order to gain access to the Mutations system, you must first complete a secondary quest titled Turn and Face the Strange.